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目的：研究排卵期阴道脱落细胞的雌、孕激素受体。方法：自然排卵妇女、注射人绒毛膜促性腺激素（ｈｕｍａｎ ｃｈｏｒｉｏｎｉｃ ｇｏｎａｄｏｔｒｏｐｉｎ，ｈＣＧ）促排卵妇女排卵期阴道脱落细胞，应用免疫组织化学ＡＢＣ 法和图像分析技术进行雌激素受体（ｅｓｔｒｏｇｅｎｒｅｃｅｐｔｏｒ，ＥＲ） 和孕激素受体（ｐｒｏｇｅｓｔｅｒｏｎｅｒｅｃｅｐｔｏｒ，ＰＲ）的定位和定量研究。结果：两组组内排卵前、后阴道脱落细胞ＥＲ比较均无差异；注射ｈＣＧ 后阴道脱落细胞的ＥＲ在排卵前和排卵后均较自然排卵组有明显增高；自然排卵组ＰＲ在排卵后较之排卵前明显升高。结论：排卵前后阴道上皮细胞ＥＲ 无明显变化；ｈＣＧ可提高阴道上皮细胞ＥＲ 水平；排卵后阴道上皮细胞ＰＲ增加。
Objective: To study the estrogen and progesterone receptors of vaginal exfoliative cells during ovulation. Methods: Women with spontaneous ovulation were injected with human chorionic gonadotropin (hCG) to induce vaginal exfoliation in ovulation. Immunohistochemical ABC and image analysis were used to detect estrogen receptor (ER ) And progesterone receptor (PR) localization and quantitative study. Results: There was no difference in ER between the two groups before and after ovulation; the ER of vaginal exfoliated cells after hCG injection was significantly higher than that before spontaneous ovulation and ovulation; PR after ovulation in ovulation group Before ovulation significantly increased. Conclusion: There was no significant change of ER in vaginal epithelial cells before and after ovulation; hCG increased the level of ER in vaginal epithelial cells; PR in vaginal epithelial cells increased after ovulation.