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据《中华检验医学杂志》2001年9月24卷第5期报道 唐山市工人医院检验科陈梦芝等,为探讨人类白细胞(HLA)Ⅰ、Ⅱ抗原与肾综合征出血热易感的相关性,应用免疫血清学方法检测了59例肾综合征出血热患者和60名正常对照者的HLA-Ⅰ类抗原型;以序列特异性引物聚合酶链反应扩增(SSP/PCR)技术鉴定HLA-DRB_1、B_3、B_4和B_5基因型及等位基因频率。 结果表明,肾综合征出血热患者组HLA-Ⅰ类A1抗原频率明显高于对照组,两组间频率分别为22％和8％;患者组DRB_1*15和
According to the “Chinese Journal of Laboratory Medicine,” September 2001 Volume 24, No. 5 report Tangshan Workers’ Hospital Department of Laboratory Chen Mengzhi, etc., in order to investigate the human leukocyte (HLA) Ⅰ, Ⅱ antigen and renal syndrome associated with hemorrhagic fever susceptibility, application Immuno-serological methods were used to detect the HLA-Ⅰ antigenicity in 59 cases of hemorrhagic fever with renal syndrome and 60 normal controls. HLA-DRB_1 was identified by SSP / PCR with sequence-specific polymerase chain reaction amplification (SSP / PCR) B_3, B_4 and B_5 genotype and allele frequency. The results showed that the frequency of HLA class Ⅰ A1 antigen in patients with hemorrhagic fever with renal syndrome was significantly higher than that in the control group with frequency of 22% and 8%, respectively. The DRB_1 * 15 and