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目的研究并分析唑来膦酸与化疗联用治疗方案针对恶性肿瘤骨转移疼痛患者的临床疗效与价值。方法选取我院自2012年1月至2012年6月所收治的恶性肿瘤骨转移疼痛患者共计52例为研究对象,按照随机抽取的方式分为观察组与对照组,每组患者各计26例。观察组采取唑来膦酸与化疗联用治疗方案,对照组采取化疗治疗方案。治疗期间为2个周期。针对两组患者骨转移疼痛缓解情况进行详细比较与分析。结果观察组疼痛缓解总有效率为88.46%(23/26),对照组疼痛缓解总有效率为65.38%(17/26)。观察组患者疼痛缓解总有效率明显高于对照组患者,两组数据组间比较差异显著(P<0.05),差异有统计学意义。结论采取唑来膦酸联合化疗方式针对恶性肿瘤骨转移患者进行临床治疗,有着疗效确切、显效时间短等特点,综合优势显著,值得临床应用与推广。
Objective To study and analyze the clinical efficacy and value of combination of zoledronic acid and chemotherapy in the treatment of patients with malignant bone metastasis. Methods A total of 52 patients with malignant tumor of bone metastasis who were treated in our hospital from January 2012 to June 2012 were selected as study objects and randomly divided into observation group and control group, with 26 patients in each group . The observation group was treated with zoledronic acid combined with chemotherapy and the control group with chemotherapy. During the treatment period of 2 cycles. For the two groups of patients with pain relief of bone metastasis compared and analyzed in detail. Results The total effective rate of pain relief was 88.46% (23/26) in the observation group and 65.38% (17/26) in the control group. The total effective rate of pain relief in the observation group was significantly higher than that in the control group, with significant difference between the two data sets (P <0.05). The difference was statistically significant. Conclusion Zoledronic acid combined with chemotherapy for patients with malignant bone metastases for clinical treatment, with the exact effect, the effective time is short, the comprehensive advantages of significant, worthy of clinical application and promotion.