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目的:研究免疫增强剂胸腺五肽的合成路线,以降低合成成本。方法:采用最小保护液相逐步接肽合成策略,即氨基酸的侧链功能基在不发生较大副反应前提下尽量不采取保护。结果:采用该策略可得到合格的产品,且合成纯化总产率达到35%。结论:该胸腺五肽合成路线成本低,环保,易产业化。
OBJECTIVE: To study the synthetic route of immunopotentiator thymopentin to reduce the cost of synthesis. Methods: Minimal protection liquid phase peptide synthesis strategy, that is, the amino acid side chain function in the absence of major side effects under the premise of not taking protection. Results: Qualified products were obtained with this strategy and the total yield of synthetic purification reached 35%. Conclusion: The thymopentin synthesis route is low cost, environmental protection, easy industrialization.