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目的探讨血清同型半胱氨酸(HCY)、叶酸(FA)、维生素B12(VitB12)水平与急性冠脉综合征(ACS)之间的关系。方法应用全自动生化分析仪及化学发光仪分别检测130例ACS患者(研究组)和212例健康体检者(对照组)血清中HCY、FA、VitB12水平并比较各组之间的差异。结果 ACS的血清HCY水平显著高于正常对照组(P<0.01),而FA浓度明显低于正常对照组(P<0.01);ACS患者血清HCY浓度与血清FA浓度呈负相关(r=-0.627,P<0.01);ACS患者中心肌梗死组的血清HCY明显高于心绞痛组(P<0.01)。ACS患者维生素B12水平与正常对照组比较无明显差异(P>0.05)。结论血清HCY浓度增高与FA水平下降是ACS的一个重要的危险因素。检测血清HCY和FA浓度可作为评价和预测ACS一个敏感可信的指标。
Objective To investigate the relationship between serum homocysteine (HCY), folic acid (FA), vitamin B12 (VitB12) levels and acute coronary syndrome (ACS). Methods The levels of HCY, FA and VitB12 in serum of 130 ACS patients (study group) and 212 healthy controls (control group) were detected by automatic biochemical analyzer and chemiluminescence analyzer. The difference between the two groups was compared. Results Serum HCY levels in ACS group were significantly higher than those in normal control group (P <0.01), while FA concentrations in ACS group were significantly lower than those in normal control group (P <0.01). Serum HCY concentration was negatively correlated with serum FA concentration (r = -0.627 , P <0.01). The serum HCY in myocardial infarction group was significantly higher than that in the angina group (P <0.01). The level of vitamin B12 in patients with ACS had no significant difference compared with the normal control group (P> 0.05). Conclusion The increase of serum HCY concentration and FA level is an important risk factor of ACS. Detection of serum HCY and FA concentrations can be used as a sensitive and reliable indicator for the evaluation and prediction of ACS.