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目的：探讨高频焊接仪（HFWD）闭合动脉血管的安全性与可靠性。方法：将6头西藏小型猪均随机分为HFWD组与超声刀组（HS组），全麻后分离裸化颈、股动脉，分别采用HFWD与HS闭合离断血管。比较两组血管闭合后的爆破压、闭合时间、闭合过程中的最高温度及闭合处病理热损伤。结果：不区分血管管径大小时，HFWD组平均爆破压高于HS组（489.64mmHgvs.439.88mmHg， P0.05），对于直径>3~5mm、>5~7mm的血管，HFWD组爆破压均大于HS组（457.02mmHgvs.404.32mmHg；418.51mmHgvs.342.84mmHg，均P3~5 mm or>5~7 mm, the burst pressure in HFWD group was significantly higher than that in HS group (457.02 mmHg vs. 404.32 mmHg; 418.51 mmHg vs. 342.84 mmHg, both P<0.05). No matter what the vessel diameter was, the sealing time in HFWD group was significantly shorter than that in HS group (all P<0.05). The average maximum temperature during sealing in HFWD group was significantly lower than that in HS group (65.91℃vs. 105.25℃, P<0.05). The collagen denaturation and smooth muscle injury in vascular wall of the sealing site were milder in HFWD group than those in HS group. Conclusion:Using HFWD for arterial closure is safe and reliable.