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目的:探讨绝经前后妇女血清胰岛素样生长因子-1(IGF-1)水平增高与乳腺癌发病的相关程度。方法:通过PubMed、Medline、CNKI、和维普检索1993-2007年已发表的IGF-1和乳腺癌关系的病例对照研究或队列研究文献资料,剔除不符合要求的文献,分类后应用Stata9.0软件进行一致性检验和数据合并。结果:6篇病例对照研究及5篇队列研究,共11篇文献入选;与对照组相比,未绝经妇女IGF-1的高水平与乳腺癌的发生有明显相关性,P<0.01,合并OR值为1.57,95%CI(1.26～1.95);而在绝经后妇女中,高水平的IGF-1与乳腺癌发生没有明显相关性,P=0.384,合并OR值为1.11,95%CI(0.88～1.39)。结论:对绝经前的人群检测血清IGF-1水平有助于筛选和确定乳腺癌高危患者,有利于早期诊断及判断预后。
Objective: To investigate the correlation between serum insulin-like growth factor-1 (IGF-1) levels and the incidence of breast cancer in premenopausal and postmenopausal women. METHODS: PubMed, Medline, CNKI, and VIP were searched for published case-control or cohort literature data from 1993 to 2007 on the relationship between IGF-1 and breast cancer, and the unqualified literature was excluded. After classification, Stata 9.0 software Conduct consistency checks and data consolidation. Results: There were 6 case-control studies and 5 cohort studies, and 11 articles were included. Compared with the control group, there was a significant correlation between the high level of IGF-1 and the occurrence of breast cancer in non-menopausal women (P <0.01) In postmenopausal women, there was no significant correlation between high levels of IGF-1 and breast cancer (P = 0.384, OR = 1.11, 95% CI, 0.88 ~ 1.39). Conclusion: Detecting serum IGF-1 levels in premenopausal women is helpful for screening and identifying high-risk patients with breast cancer, which is good for early diagnosis and prognosis.