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目的:分析我国最低海拔地区吐鲁番维吾尔族成人支气管哮喘的危险因素,为哮喘防治工作提供参考依据。方法:采用1∶1配对设计,选择2005年9月~2006年8在吐鲁番地区医院确诊的门诊及住院的维吾尔族哮喘患者86例(哮喘组)及同期眼科门诊就诊病人86例(对照组)。制定统一的调查表,对所有研究对象进行哮喘危险因素调查及常见血清变应原S-IgE检测,进行单因素分析及多因素的条件Logistic回归分析,并检测中、重度哮喘患者及其对照者血清炎症介质S-ECP、T-IgE水平检测。结果:维吾尔族成人哮喘发作的主要危险因素有呼吸道感染、家族史(一级亲属)、气候变化、过敏史、S-IgE阳性(P<0.05)。哮喘组中、重度哮喘患者血清S-ECP、T-IgE水平明显高于对照组(P<0.01)。结论:呼吸道感染、家族史、气候变化、过敏史为维吾尔族成人哮喘发作的主要危险因素;血清S-ECP、T-IgE水平能反映哮喘气道炎症的活动情况。
OBJECTIVE: To analyze the risk factors of adult bronchial asthma in Uighur Turpan in the lowest elevations in our country, and to provide a reference for the prevention and treatment of asthma. Methods: A one-to-one paired design was used to select 86 outpatients and hospitalized patients with asthma in Urumqi (asthma group) and 86 patients (control group) during the same period from September 2005 to August 2006 in ophthalmology clinic. . To develop a unified questionnaire, all subjects were investigated for asthma risk factors and common serum allergen S-IgE test, univariate analysis and conditional Logistic regression analysis, and detection of moderate and severe asthma patients and their controls Serum inflammatory mediators S-ECP, T-IgE levels were detected. Results: The main risk factors of adult asthma in Uygur were respiratory infection, family history (first degree relatives), climate change, history of allergy and S-IgE positive (P <0.05). Serum levels of S-ECP and T-IgE in asthma group were significantly higher than those in control group (P <0.01). Conclusions: Respiratory infections, family history, climate change and allergy history are the major risk factors for asthma attacks in adults. The levels of serum S-ECP and T-IgE reflect the activity of airway inflammation in asthma.