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目的探讨卵巢上皮肿瘤各亚型中雌激素受体α(ERα)及靶蛋白孕激素受体(PR)、E-钙黏着蛋白(E-cad-herin)间表达的相关性及临床意义。方法对解放军总医院2001年1月至2006年1月经病理检查证实的67例卵巢癌标本[5例浆液性交界性腺癌、46例浆液性腺癌(SAC)、6例子宫内膜样腺癌(MAC)、5例透明细胞癌(CCA)及5例其它恶性肿瘤亚型],采用免疫组化SP法检测其ERα、PR、E-cadherin的表达情况,结合临床病理特征分析3种蛋白间表达的关系。结果(1)浆液性交界性卵巢癌、SAC、MAC、CCA中ERα表达阳性率分别为:40.0%、76.08%、66.67%、0;PR表达阳性率分别为:60.00%、82.61%、66.67%、0;E-cadherin表达阳性率分别为:100.00%、95.65%、100.00%、100.00%;SAC与CCA间ERα、PR的表达阳性率差异有统计学意义(P<0.05)。(2)E-cadherin的表达与SAC临床分期存在相关性(r=0.3610,P<0.05)。(3)SAC中,各临床病理特征(临床分期、病理学分级、年龄、淋巴转移)进行内部比较ERα、PR、E-cadherin的表达阳性率无明显差异。(4)浆液性卵巢癌中ERα、PR、E-cadherin的表达未检测出相关性(P>0.05)。结论ERα可能成为临床区分CCA和SAC的一项重要特征;E-cadherin可能在SAC的癌变过程中起重要作用,对临床诊断及预后评估具有一定的指导意义。
Objective To investigate the correlation and clinical significance of estrogen receptor α (ERα) and progesterone receptor (PR), E-cadherin (E-cadherin) expression in various subtypes of epithelial ovarian tumors. Methods Sixty-seven ovarian cancer samples confirmed by pathological examination from January 2001 to January 2006 in the People’s Liberation Army General Hospital [5 cases of serous borderline adenocarcinoma, 46 cases of serous adenocarcinoma (SAC), 6 cases of endometrial adenocarcinoma MAC), 5 cases of clear cell carcinoma (CCA) and 5 cases of other malignant tumors. The expressions of ERα, PR and E-cadherin were detected by immunohistochemical SP method. The expressions of three proteins were analyzed by clinicopathological features Relationship. Results (1) The positive rates of ERα expression in serous borderline ovarian cancer, SAC, MAC and CCA were 40.0%, 76.08%, 66.67%, 0 respectively. The positive rates of PR expression were 60.00%, 82.61%, 66.67% , Respectively. The positive rates of E-cadherin expression were 100.00%, 95.65%, 100.00% and 100.00%, respectively. The positive rates of ERα and PR in SAC and CCA were significantly different (P <0.05). (2) The expression of E-cadherin correlated with the clinical stage of SAC (r = 0.3610, P <0.05). (3) The positive rates of ERα, PR and E-cadherin expression in SAC were not significantly different among all clinical pathological features (clinical stage, pathological grade, age, lymph node metastasis). (4) No correlation was found between ERα, PR and E-cadherin in serous ovarian cancer (P> 0.05). Conclusions ERα may be an important feature of differentiating between CCA and SAC clinically. E-cadherin may play an important role in the carcinogenesis of SAC, which may be of guiding significance in clinical diagnosis and prognosis evaluation.