论文部分内容阅读
目的:探讨促红细胞生成素(Epo)多克隆抗体是否具有拮抗Epo所致的高原红细胞增多症患者骨髓红系增殖活性的功能。方法:抽取高原红细胞增多症病人骨髓,分离单个核细胞,进行红系定向体外培养,观察加入Epo及Epo多克隆抗体对红系集落形成单位(CFU-E)的影响。结果:Epo多克隆抗体体外能抑制高原红细胞增多症病人骨髓红系增殖。结论:Epo抗体可以显著拮抗Epo促红细胞增生作用。
Objective: To investigate whether erythropoietin (Epo) polyclonal antibodies can antagonize erythropoietic erythropoietic proliferative activity in Epo-induced patients with high altitude polycythemia. Methods: Bone marrow of patients with high altitude polycythemia were isolated, mononuclear cells were isolated and cultured in vitro. The effects of Epo and Epo polyclonal antibody on erythrocyte formation unit (CFU-E) were observed. Results: Epo polyclonal antibody could inhibit erythrocyte proliferation in patients with high altitude polycythemia in vitro. Conclusion: Epo antibody can significantly antagonize Epo erythropoietic effect.