Dubin-Johnson综合征为先天性胆红素排泄障碍,各年龄组均可发病,以青春期发病居多数。作者曾遇 3 例均于婴儿期发病,开始误诊为婴儿肝炎,之后均经肝穿确诊为本病。此系国内报道本病中之年龄组最小者。本文报道此 3 例病例,并就婴儿期Dubin-Johnson综合证的诊断问题进行讨论. Dubin-Johnson syndrome congenital bilirubin excretion disorder, all age groups can be onset, the majority of adolescent onset. The authors have encountered in 3 cases were infantile onset, misdiagnosed as infant hepatitis, were diagnosed as liver disease after the disease. This is the domestic coverage of the disease in the smallest age group. This article reports the three cases and discusses the diagnosis of infantile Dubin-Johnson syndrome.