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目的:研究秋茄枝乙醇提取物(EEK)对链脲佐菌素(STZ)诱导的2型糖尿病(T2DM)大鼠肝脏和胰腺组织病理结构的影响。方法:以高脂饲料喂养联合STZ建立T2DM大鼠模型。大鼠分为为正常对照组、T2DM模型组、二甲双胍组、EEK低、中、高剂量组。大鼠给药4周后处死,取肝脏和胰腺进行组织病理学检查。结果:随着EEK剂量的增加,大鼠肝脏和胰岛组织的病理损伤逐步减轻。结论:EEK有助于修复STZ诱导的T2DM大鼠受损的肝脏和胰岛组织。
Objective: To study the effects of ethanol extract of candelilla (EEK) on pathological changes of liver and pancreas in rats with type 2 diabetes mellitus (T2DM) induced by streptozotocin (STZ). Methods: T2DM rats were established by feeding high fat diet combined with STZ. Rats were divided into normal control group, T2DM model group, metformin group, EEK low, medium and high dose groups. Four weeks after the administration, rats were sacrificed, and the liver and pancreas were taken for histopathological examination. Results: With the increase of EEK dose, the pathological damage of liver and islet in rats gradually reduced. Conclusion: EEK helps repair damaged liver and pancreatic islets in STZ-induced T2DM rats.