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目的 探讨血管形成与大肠癌侵袭、转移的关系及在肠粘膜癌变过程中的作用。方法 应用免疫组化法检测 15 5例大肠癌石蜡切片微血管数量 (MVC) ,分析MVC与临床病理因素、预后及大肠粘膜癌变的关系。结果 MVC与大肠癌浸润深度、组织学类型、淋巴结转移、Dukes分期、肝脏转移密切相关 ,而与肿瘤大小无关。高MVC(≥ 98)大肠癌患者比低MVC( <98)者 5年生存率明显降低。随着肠粘膜由良性向恶性的转变 ,MVC明显增加 (P <0 .0 1)。结论 MVC对大肠癌患者的预后有一定意义。
Objective To investigate the relationship between angiogenesis and the invasion and metastasis of colorectal cancer and its role in the carcinogenesis of intestinal mucosa. Methods Immunohistochemistry was used to detect the number of microvessels (MVC) in paraffin sections of 153 patients with colorectal cancer. The relationship between MVC and clinicopathological factors, prognosis and colorectal mucosal carcinogenesis was analyzed. Results MVC was closely related to the depth of invasion, histological type, lymph node metastasis, Dukes stage, and liver metastasis of colorectal cancer, but not related to tumor size. Patients with high MVC (≥ 98) colorectal cancers had significantly lower 5-year survival rates than those with low MVC (<98). As the intestinal mucosa changed from benign to malignant, MVC increased significantly (P < 0.01). Conclusion MVC has a certain significance for the prognosis of patients with colorectal cancer.