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目的探讨苯磺酸左旋氨氯地平与瑞舒伐他汀钙联合治疗对原发性高血压病患者颈动脉硬化的影响。方法选择2009年2月至2010年2月原发性高血压并颈动脉硬化患者80例,随机分为对照组(40例)和试验组(40例)。对照组使用苯磺酸左旋氨氯地平2·5mg,1次/d,2周后,血压未达标者,增加剂量至5mg,试验组同时口服瑞舒伐他汀钙10mg,1次/晚,疗程为48周。比较两组治疗前、后的颈动脉IMT、血压、血脂、hsCRP的变化。结果服药48周后,两组IMT、BP均较治疗前明显降低(P<0·05);其中试验组IMT降低更明显(P<0·05)。试验组TG、TC、LDL-C、hsCRP明显下降,HDL-C明显增高,与治疗前及对照组治疗前、后比较,差异均有统计学意义(P<0·05)。结论苯磺酸左旋氨氯地平与瑞舒伐他汀钙联合对颈动脉IMT作用明显,能有效延缓?逆转原发性高血压病患者颈动脉粥样硬化进展。
Objective To investigate the effect of levamlodipine besylate combined with rosuvastatin calcium on carotid atherosclerosis in patients with essential hypertension. Methods 80 patients with essential hypertension and carotid atherosclerosis from February 2009 to February 2010 were randomly divided into control group (40 cases) and experimental group (40 cases). The control group levamlodipine besylate 2.5mg, 1 times / d, 2 weeks later, the blood pressure did not meet the standard, increasing the dose to 5mg, the test group also orally rosuvastatin calcium 10mg, 1 / night, treatment For 48 weeks. The changes of carotid IMT, blood pressure, blood lipid and hsCRP in two groups before and after treatment were compared. Results After 48 weeks of treatment, the IMT and BP of both groups were significantly lower than those before treatment (P <0.05). The decrease of IMT in the experimental group was more obvious (P <0.05). The levels of TG, TC, LDL-C and hsCRP in the experimental group were significantly decreased, and HDL-C was significantly increased. There were significant differences between the two groups before and after treatment (P <0.05). Conclusion L-amlodipine besylate combined with rosuvastatin calcium has obvious effect on carotid artery IMT, which can effectively delay and reverse the progression of carotid atherosclerosis in patients with essential hypertension.