论文部分内容阅读
目的探究异丙托溴铵联合沙丁胺醇及布地奈德雾化吸入治疗小儿毛细支气管炎的临床疗效。方法以该院收治的91例小儿毛细支气管炎患儿为研究对象,按照入院治疗的先后顺序将其分为联合组和对照组。对照组患儿给予常规雾化吸入及抗感染治疗,联合组患儿则在常规抗感染治疗的基础上采用异丙托溴铵联合沙丁胺醇及布地奈德进行三联雾化治疗。对比两组患儿的主要症状及体征消失时间,并就治疗前后两组患儿的肺功能及相关的炎性因子水平进行比较。就两组患儿在出院后3个月内及6个月内的喘息发作频率和喘息持续时间进行对比分析。结果两组患儿的主要症状及体征主要表现有发热、咳嗽、气喘、有哮鸣音,联合组的各主要症状、体征消失时间以及住院时间均明显低于对照组,差异有统计学意义(均P<0.05)。治疗前,两组患儿的各项肺功能水平以及血清内降钙素原(PCT)、C反应蛋白(CRP)水平比较差异无统计学意义(均P>0.05);治疗后,两组患儿的潮气量(TV)、达峰时间比(t PTEF/t E)和达峰容积比(VPTEF/VE)等肺功能指标水平均有所提升,PCT及CRP水平均有所下降,联合组的各项指标改善幅度明显大于对照组,差异有统计学意义(均P<0.05)。而联合组在出院后3个月内、6个月内的喘息发作频率及喘息持续时间均明显低于对照组,组间比较差异有统计学意义(均P<0.05)。结论异丙托溴铵联合沙丁胺醇及布地奈德雾化吸入在治疗小儿毛细支气管炎上效果显著,患儿的主要症状、体征以及肺功能状态均能够迅速改善,机体内炎性反应得到有效控制,临床疗效明显优于常规雾化吸入治疗。
Objective To investigate the clinical efficacy of ipratropium bromide combined with salbutamol and budesonide inhalation in the treatment of children with bronchiolitis. Methods A total of 91 pediatric patients with bronchiolitis admitted to the hospital were enrolled in this study. The patients were divided into two groups according to the sequence of admission and treatment: combination group and control group. Children in the control group were given conventional inhalation and anti-infection therapy. In combination group, children were treated with ipratropium bromide plus salbutamol and budesonide for triple therapy on the basis of conventional anti-infective therapy. The main symptoms and signs of the two groups were compared, and the lung function and related inflammatory factors of the two groups were compared before and after treatment. The frequency of wheezing episodes and duration of wheeze were compared between the two groups within 3 months and within 6 months after discharge. Results The main symptoms and signs of the two groups were fever, cough, asthma, wheeze, the main symptoms of the combination group, the disappearance of signs and hospitalization time were significantly lower than the control group, the difference was statistically significant ( All P <0.05). Before treatment, the levels of pulmonary function and serum procalcitonin (PCT) and C-reactive protein (CRP) in two groups had no significant difference (all P> 0.05); after treatment, The levels of tachyphylaxis (TV), t PTEF / t E and VPTEF / VE increased, while the levels of PCT and CRP decreased. The combined group Of the indicators of improvement was significantly greater than the control group, the difference was statistically significant (P <0.05). However, the frequency of wheezing episodes and duration of wheeze within 3 months and 6 months after the discharge in the combined group were significantly lower than those in the control group. There was significant difference between the two groups (all P <0.05). Conclusions Ipratropium bromide combined with salbutamol and budesonide inhalation is effective in treating bronchiolitis in children. The main symptoms, signs and pulmonary function status of children can be rapidly improved, and the inflammatory reaction in the body can be effectively controlled. The clinical The efficacy is obviously better than the conventional inhalation therapy.