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材料和方法作者共观察173名复发性疱疹性口炎(PRC)小儿患者,其中有10名年龄3～5岁的儿童表现为持续性病变。根据临床表现、既往史及口腔病变部位刮除材料的细胞和免疫荧光检查确诊。在治疗过程中测定体液及局部免疫指标。采用荧光抗体法测定血清和唾液中抗疱疹病毒抗体滴度。血清和唾液中各种免疫球蛋白含量采用琼脂放射免疫扩散法测定。研究结果及讨论所有患儿在疾病初期均采用一些目前使用的全身及局部治疗方法,但作者很快发现治疗效果不佳,虽然也曾出现过短期缓解,10名患儿无1例取得治疗成功。鉴于此对全部患儿进行血和唾液的免疫学检查,发现小儿均存在明显的免疫功能不足,决定采用免疫刺激疗法。作为全身和局部治疗的补充,使用几个疗程的核酸钠和甲基脲嘧啶治疗,每个疗程10～20天。剂量视小儿年龄而定,可惜疗效甚微。10人中仅3人的复发间隔时间延长到2～4天。给患儿使用左旋咪唑50mg/天,2次/周,经过5～10周治疗见所有儿童均可很好地耐受这种药物,无1例出现已知的恶心、呕吐、食欲下降、腹泻、口腔金
Materials and Methods A total of 173 children with recurrent vesicular stomatitis (PRC) were observed, of whom 10 were children aged 3 to 5 years with persistent disease. According to clinical manifestations, past history and oral lesions curettage material cells and immunofluorescence confirmed. Determination of body fluids and local immune indicators during treatment. The anti-herpesvirus antibody titers in serum and saliva were determined by fluorescent antibody method. Serum and saliva in a variety of immunoglobulin content by agar radioimmunoassay determination. RESULTS AND DISCUSSION All children underwent initial systemic and local treatment at the beginning of their illness. However, the authors soon found that the treatment did not work well. Although short-term remissions had also occurred, none of the 10 children had successful treatment . In view of this immunological examination of all children with blood and saliva, found that children have obvious immune deficiency, decided to use immunostimulatory therapy. As a supplement to systemic and topical therapies, several courses of sodium and methyluracil are used, each for 10 to 20 days. The dose depends on the age of the child, but unfortunately with little effect. Only 10 out of 10 relapse interval extended to 2 to 4 days. Levamisole 50 mg / day, 2 times / week for children, all children were well tolerated after 5 to 10 weeks of treatment, none of the known nausea, vomiting, loss of appetite, diarrhea , Oral gold