目的探讨围生期脑静脉血栓形成与凝血因子V Leiden突变的关系。方法应用聚合酶链反应-限制性片段长度多态性PCR技术(PCR-RFLP)对广州地区汉族8例围生期脑静脉血栓形成及50例正常妊娠妇女进行凝血因子V Leiden突变研究分析。结果58例研究对象中未发现凝血因子V Leiden突变。结论FVL突变作为广州地区汉族妇女围生期脑静脉血栓形成的主要危险因素的可能性较小,广州地区汉族妇女FVL突变率较低。 Objective To investigate the relationship between perinatal cerebral venous thrombosis and coagulation factor V Leiden mutation. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the clonogenic V Leiden mutation in 8 patients with perinatal cerebral venous thrombosis and 50 normal pregnant women in Guangzhou Han nationality. RESULTS: No clotting factor V Leiden mutation was found in 58 subjects. Conclusions FVL mutation is less likely to be a major risk factor for perinatal cerebral venous thrombosis in Han Chinese women in Guangzhou. The frequency of FVL mutations in Han women in Guangzhou is relatively low.