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目的:研究金丝小枣糖浆对动物机体免疫功能的影响。方法:将48只雌性昆明种小鼠按体重随机分为4组,即1个溶剂对照组(蒸馏水)和3个金丝小枣糖浆剂量组(1.25、2.50、5.00mL/kgBW),每组12只。每天定时灌胃(采用等体积灌胃法,0.2mL/10gBW)各组动物,连续28d。选择淋巴器官相对质量、脾脏抗体生成细胞数、半数溶血值(HC50)、脾淋巴细胞转化试验、迟发型变态反应试验、碳粒廓清试验等免疫学指标和方法,从体液免疫、细胞免疫和巨噬细胞吞噬功能等不同角度全面研究金丝小枣糖浆对动物机体的免疫功能是否存在调节作用。结果:灌胃2.50、5.00mL/kgBW剂量的金丝小枣糖浆,小鼠的足跖肿胀度、脾脏抗体生成细胞数明显增加,3个剂量组的HC50均明显增加,中剂量组小鼠的碳粒廓清指数和腹腔巨噬细胞吞噬指数均较对照组明显提高。结论:一定剂量的金丝小枣糖浆能提高正常昆明种小鼠的体液免疫和细胞免疫功能。
Objective: To study the effects of Jizo jujube syrup on immune function of animals. Methods: Forty-eight female Kunming mice were randomly divided into 4 groups according to body weight: 1 solvent control group (distilled water) and 3 gold jujube syrup dose groups (1.25, 2.50 and 5.00 mL / kg BW) 12 only. Every day regular gavage (using the same volume gavage method, 0.2mL / 10gBW) each group of animals, continuous 28d. Select the relative quality of lymphoid organs, the number of spleen antibody producing cells, half hemolytic value (HC50), splenic lymphocyte transformation test, delayed allergy test, carbon clearance test and other immunological indicators and methods, from humoral immunity, cellular immunity and giant Phagocytosis of phagocytic function of different perspectives such as a comprehensive study of golden jujube syrup on the immune function of the body there is regulation. Results: The gingiva jujube syrup with doses of 2.50 and 5.00 mL / kg BW dose significantly increased the paw edema and spleen antibody production in all three groups, Carbon clearance index and peritoneal macrophage phagocytic index were significantly higher than the control group. Conclusion: A certain dose of Jizo jujube syrup can improve the humoral and cellular immunity of normal Kunming mice.