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目的:利用质子磁共振波谱(1H-MRS)技术研究帕金森病(PD)患者纹状体的代谢变化,评价H-MRS1用于PD的病理生理研究和诊断的价值。方法:采用H-MRS检测15例PD与12例年龄匹配的健康对照者双侧纹状体1N-乙酰天门冬氨酸(NAA)、胆碱复合物(Cho)及肌酸复合物(Cr)含量,比较NAA/Cr、Cho/Cr、NAA/Cho比值。结果:PD组NAA/Cr、Cho/Cr、NAA/Cho分别为(1.2±0.15)、(0.9±0.13)、(1.1±0.14),对照组分别为(1.8±0.12)、(0.9±0.15)、(1.4±0.13)。PD组NAA/Cr、NAA/Cho值减低,与对照组比较差异有统计学意义(P<0.05)。结论:NAA/Cr、NAA/Cho值降低是评估PD患者神经元功能损害的重要指标。1H-MRS对PD患者双侧纹状体进行检测,可以为PD患者的病理生理改变和诊断提供重要信息。
Objective: To study the metabolic changes of striatum in Parkinson’s disease (PD) by proton magnetic resonance spectroscopy (1H-MRS) and to evaluate the value of H-MRS1 in the pathophysiology and diagnosis of PD. Methods: The levels of NAA, Cho and creatine complex (Cr) in bilateral striatum of 15 PD and 12 age-matched healthy controls were detected by H-MRS. Content, compare NAA / Cr, Cho / Cr, NAA / Cho ratio. RESULTS: The NAA / Cr, Cho / Cr and NAA / Cho ratios in PD group were (1.2 ± 0.15) and (0.9 ± 0.13) and (1.1 ± 0.14) , (1.4 ± 0.13). The NAA / Cr and NAA / Cho values in PD group decreased compared with those in control group (P <0.05). Conclusion: The decrease of NAA / Cr, NAA / Cho values is an important index to evaluate the functional impairment of neurons in PD patients. 1H-MRS detection of PD patients with bilateral striatum, PD patients with pathophysiological changes and diagnosis can provide important information.