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目的 :观察吸烟对食管下段括约肌压力 (loweresophagealsphincterpressure,LESP)、食管体部蠕动波幅度 (peristalsisamplitude,PA)及反流频数 (refluxfrequency ,RF)的影响 ,推断吸烟是否与反流性食管炎发病有关。 方法 :5 1例吸烟者中有 36例反流性食管炎和 15例健康人 ,将他们分别与 36例不吸烟的反流性食管炎患者及 15例不吸烟健康志愿者配对 ,对该 10 2例受试者进行食管动力和 pH值监测。结果 :食管炎患者的LESP及PA显著低于健康人 ,而RF显著高于健康人 (P <0 .0 1和P <0 .0 5 )。食管炎患者中吸烟组LESP及PA低于非吸烟组 ,而RF显著高于非吸烟组 (P <0 .0 1) ,在健康人中吸烟组LESP低于非吸烟组 (P <0 .0 5 ) ,PA及RF与非吸烟组相比无明显差别 (P >0 .0 5 )。结论 :吸烟可降低LESP和PA ,增加RF ,导致食管动力异常 ,可能是反流性食管炎致病因素之一
Objective: To observe the effect of smoking on loweresophagealphincterpressure (LESP), peristalsis amplitude (PA) and reflux frequency (RF) of esophageal lower esophagus, and to determine whether smoking is related to the pathogenesis of reflux esophagitis. Methods: Thirty-six of the 51 smokers with reflux esophagitis and 15 healthy controls were matched with 36 non-smoking reflux esophagitis patients and 15 non-smoking healthy volunteers. Two subjects underwent esophageal motility and pH monitoring. Results: LESP and PA in patients with esophagitis were significantly lower than those in healthy people, while RF was significantly higher in healthy subjects (P <0.01 and P <0.05). LESP and PA in smoking group were lower than those in non-smoking group, while RF was significantly higher in esophagitis group than in non-smoking group (P <0.01). LESP in smoking group was lower than that in non-smoking group (P <0. 0) 5), PA and RF no significant difference compared with non-smoking group (P> 0.05). Conclusion: Smoking can reduce the LESP and PA, increase the RF, resulting in abnormal esophageal motility may be one of the risk factors of reflux esophagitis