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长期以来,低蛋白饮食一直作为延缓慢性肾脏病(CKD)患者病情进展的一项重要措施在临床广泛运用。其基本原理基于长期控制饮食中的蛋白质摄入量,可明显地降轻肾小球高滤过及高代谢状态,从而达到减轻残余肾单位高压力负荷、延缓肾功能急骤恶化的目的。此外,低蛋白饮食还可减少肾功能不全患者蛋白尿及改善代谢性酸中毒;有研究证明控制高蛋白饮食在预防或改善继发性甲状旁腺功能亢进等内分泌紊乱、直接或间接调
For a long time, the low-protein diet has been widely used clinically as an important measure to delay the progression of the disease in patients with chronic kidney disease (CKD). Its basic principle is based on the long-term control of dietary protein intake, can significantly reduce glomerular hyperfiltration and high metabolic state, so as to reduce the residual nephron high pressure load, delay the purpose of rapid deterioration of renal function. In addition, low-protein diet can reduce proteinuria in patients with renal insufficiency and improve metabolic acidosis; studies have shown that the control of high-protein diet in the prevention or improvement of secondary hyperparathyroidism and other endocrine disorders, directly or indirectly transferred