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SD大鼠17只,分三组。实验组(二组)每天分别胃针灌服悬混于羧甲基纤维素钠(CMC)的雷公藤多甙,20mg/kg(6鼠)和30mg/kg(5鼠),每周6天,共4周,对照组(6鼠)灌服等量CMC。各组分别于第2和第4周各剖杀2-3只动物,主要做扫描电镜观察。结果说明GTW对附睾精子的作用可能先于睾丸,但随剂量的增大及作用时间的延长而逐渐波及曲细精管。对GTW最敏感的结构可能主要是鞭毛膜等膜性结构,对精于膜的损伤似乎先波及尾部,再损及头颈段。
Seventeen SD rats were divided into three groups. The experimental group (group 2) received gastric gavage daily with TWP containing 20 mg/kg (6 mice) and 30 mg/kg (5 mice), which was suspended in sodium carboxymethyl cellulose (CMC) for 6 days per week. For a total of 4 weeks, the control group (6 rats) was given equal amounts of CMC. Each group was killed on the 2nd and 4th week respectively and 2-3 animals were sacrificed. Scanning electron microscopy was performed. The results suggest that the effect of GTW on epididymal spermatozoa may precede the testis, but it gradually spreads to the seminiferous tubules as the dose increases and the duration of action increases. The structures most sensitive to GTW may be mainly membrane structures such as the flagellar membrane. It seems that damage to spermatic membranes first affects the tail and then damages the head and neck segments.