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目的:探究改良套入式胰肠吻合在慢性胰腺炎胰十二指肠切除术中的临床应用效果。方法:抽取2015年1月至2016年12月南阳医学高等专科学院第一附属医院收治的拟行胰十二指肠切除术的慢性胰腺炎患者73例。根据胰肠吻合方式将其分为观察组(38例)和对照组(35例)。对照组行黏膜胰肠端侧吻合，观察组行改良套入式胰肠吻合。观察并比较两组患者手术情况、术后并发症、预后情况。结果:观察组手术时间为(342.47±47.25)min，少于对照组的(392.27±56.38)min(n P<0.05)。观察组无B级和C级胰瘘发生，对照组B级和C级胰瘘发生率为25.71%(9/35)及25.71%(9/35)，差异有统计学意义(n P<0.05)。随访3年，观察组病死率(26.32%，10/38)低于对照组(51.43%，18/35)，差异有统计学意义(n P<0.05)。n 结论:改良套入式胰肠吻合在慢性胰腺炎胰十二指肠切除术中应用可简化手术流程，缩短手术时间，还能降低B级和C级胰瘘等并发症发生率，且预后较好。“,”Objective:To investigate the clinical applicability of modified nested pancreaticojejunostomy in patients with chronic pancreatitis.Methods:A total of 73 patients with chronic pancreatitis planning to receive pancreatoduodenectomy in the First Affiliated Hospital of Nanyang Medical College from January 2015 to December 2016 were selected. According to pancreaticojejunostomy methods, they were divided into observation group (38 cases) and control group (35 cases). The control group underwent end-to-side mucosal pancreaticojejunostomy anastomosis, and the observation group underwent modified nested pancreaticojejunostomy. The operation status, postoperative complications and prognosis of the two groups were observed.Results:The operation time of the observation group was (342.47±47.25)min, shorter than the (392.27±56.38)min of the control group (n P<0.05). No one of the observation group had grade B or grade C pancreatic fistula, the incidences of grade B and grade C pancreatic fistula in the control group both were 25.71%(9/35), and the difference between the two groups was significant (n P<0.05). After 3 years of follow-up, the case fatality rate of the observation group was 26.32%(10/38), lower than the 51.43%(18/35) of the control group (n P<0.05).n Conclusions:The modified nested pancreaticojejunostomy can simplify the operation process and shorten the operation time of pancreatoduodenectomy for patients with chronic pancreatitis, and also reduce the incidence of complications such as grade B and grade C pancreatic fistula, with better prognosis.