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目的研究职业性铅接触与机体氧化应激之间的关系。方法采取研究对象外周静脉血5mL,测定血铅和脂质过氧化指标含量,用SPSS10.0软件对数据进行统计分析。结果铅接触组血铅含量均明显高于对照组(P<0.05)。铅接触组作业工人血清中GSH-Px和CAT含量要低于对照组(P<0.05),而MDA含量则高于对照组(P<0.05)。结论铅冶炼作业工人铅接触水平与机体氧化损伤密切相关,铅可以诱导机体发生脂质过氧化,降低机体的抗氧化能力。
Objective To study the relationship between occupational lead exposure and oxidative stress in the body. Methods Peripheral venous blood 5 mL was used to measure the content of blood lead and lipid peroxidation. The data were analyzed by SPSS 10.0 software. Results The levels of lead in lead exposure group were significantly higher than those in control group (P <0.05). GSH-Px and CAT contents in serum of workers exposed to lead were lower than those of the control group (P <0.05), while MDA content was higher in the exposed workers (P <0.05). Conclusion Lead exposure of lead smelting workers is closely related to the oxidative damage of the body. Lead can induce lipid peroxidation and reduce the body’s antioxidant capacity.