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目的建立高效液相非接触电导检测法快速测定阿咖酚散中3种有效成分含量的新方法。方法色谱系统采用ODS反相柱,流动相:甲醇-水-乙酸(35∶60∶5),流速:1.0 m L/min,柱温:35℃,进样量:10μL,用非接触电导检测器对阿司匹林、对乙酰氨基酚、咖啡因进行分离和检测。结果阿司匹林线性范围为36.00~359.96μg/m L(r=0.986 6),平均回收率(n=9)为99.6%;对乙酰氨基酚线性范围为19.97~199.32μg/m L(r=0.986 3),平均回收率(n=9)为100.5%;咖啡因线性范围为4.9~49.04μg/m L(r=0.968 0),平均回收率(n=9)为100.1%。结论方法简便、灵敏、重复性好,适用于阿咖酚散中3种有效成分的含量测定,结果满意。
OBJECTIVE To establish a new method for the rapid determination of three active ingredients in acacia powder by high performance liquid noncontact conductivity detection. Methods The chromatographic system was characterized by ODS reverse phase column with mobile phase of methanol-water-acetic acid (35:60:5), flow rate of 1.0 mL / min, column temperature of 35 ℃, injection volume of 10 μL, On aspirin, acetaminophen, caffeine were isolated and tested. Results The linear range of aspirin was 36.00-359.96 μg / m L (r = 0.986 6) and the average recovery was 99.6% (n = 9). The linear range of acetaminophen was 19.97-199.32 μg / m L (r = 0.986 3 ), And the average recovery (n = 9) was 100.5%. The linear range of caffeine was 4.9 ~ 49.04μg / m L (r = 0.968) and the average recovery was 100.1%. Conclusion The method is simple, sensitive and reproducible. It is suitable for the determination of three effective components in acacia powder with satisfactory results.