本综述重点介绍近年来炎症性肠病(IBD)在发病机制、诊断及处理上的进展。发病机理由于IBD 本身的复杂性和表现上的多变性,故难以确定哪些特征对IBD 是必不可少的;同时由于缺少合适的动物模型使对IBD 的认识受到限制。关于IBD 发病机理的基本问题可归纳为:慢性、复发性炎症活动是对持久异常刺激(如肠结构改变或环境中致病原)的洽当反 This review highlights the recent advances in the pathogenesis, diagnosis and treatment of inflammatory bowel disease (IBD). Pathogenesis Due to the complexity and variability of IBD itself, it is difficult to determine which features are essential for IBD; at the same time, knowledge of IBD is limited by the lack of suitable animal models. The basic questions about the pathogenesis of IBD can be summarized as follows: Chronic, recurrent inflammatory activity is symptomatic of persistent anomalous stimuli (such as changes in bowel architecture or pathogenic agents in the environment)