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目的观察草酸铂(L-OHP)联合氟尿嘧啶(5-Fu)和亚叶酸钙(CF)治疗晚期大肠癌的近期疗效和毒副反应。方法经病理组织学诊断的晚期大肠癌40例,用L-OHP 130 mg/m2,静脉滴注4 h,每天1次;CF200 mg,静脉滴注2 d,继以5-Fu 375 mg/m2,微量泵泵入6 h以上,连续用5 d。每3周重复1次,作为1个治疗周期,治疗2个周期后评定疗效。结果40例总有效率为37.5%(15/40),完全缓解2例(5%),部分缓解13例(32.5%),无变化16例(40%),进展7例(17.5%)。主要的毒副作用为神经毒性、骨髓抑制、恶心呕吐等,无治疗相关性死亡患者。结论L-OHP联合大剂量CF及5-Fu治疗晚期大肠癌疗效较好,毒副反应能为患者耐受,值得临床推广应用。
Objective To observe the short-term curative effect and toxicity of L-OHP combined with 5-Fu and leucovorin in the treatment of advanced colorectal cancer. Methods Forty patients with advanced colorectal cancer diagnosed by histopathology were treated with L-OHP 130 mg / m 2 intravenously for 4 h once a day, and CF 200 mg for 2 d followed by 5-Fu 375 mg / m 2 , Micro-pump pump more than 6 h, with 5 d. Repeat once every 3 weeks, as a treatment cycle, after 2 cycles of assessment of curative effect. Results The total effective rate was 37.5% (15/40) in 40 cases, complete remission in 2 cases (5%), partial remission in 13 cases (32.5%), no change in 16 cases (40%) and progression in 7 cases (17.5%). The main toxic and side effects of neurotoxicity, bone marrow suppression, nausea and vomiting, no treatment-related deaths. Conclusion L-OHP combined with high-dose CF and 5-Fu in the treatment of advanced colorectal cancer has good curative effect and toxicity can be tolerated in patients. It is worthy of clinical application.