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以邻苯二甲酸醋酸纤维素为成球材料、促肝细胞生长素为球心物，制备工艺经均匀设计优化，制得类白色粉末状微球。高效液相色谱（HPLC）测得微球包封的药物图谱与促肝细胞生长素的HPLC图谱一致。微球载药量量29．7±2．5％，平均粒径127um。微球在人工胃液中2h释药不超过10％，在人工肠液中2h，释药100％。微球给大鼠灌胃后，HPLC测得大鼠血中促肝细胞生长素浓度在2．5h最高。
Phthalate cellulose acetate as the material into the ball, promote hepatocyte growth hormone as the center of the ball, the preparation process by uniform design and optimization, prepared white powder-like microspheres. High performance liquid chromatography (HPLC) measured microspheres encapsulated drug profiles and promote hepatocyte growth hormone HPLC profiles. The amount of drug loaded microspheres 29.7 ± 2.5%, the average particle size of 127um. Microspheres in artificial gastric juice 2h release of not more than 10% in artificial intestinal fluid 2h, release 100%. After intragastric administration of microspheres to rats, HPLC assay showed that the concentration of hepatocyte growth-promoting hormone in rat blood was the highest at 2.5h.