本文报道光学纯美登醇、美登素的合成。合成的美登醇、美登素的各项物理常数和光谱数据包括薄层层析行为、熔点、比旋度、高速液相、紫外光谱、圆二色散谱、红外光谱、核磁共振和质谱等与天然美登醇、美登素的完全一致。生物试验表明合成的美登素与天然的美登素具有相同的抗肿瘤活性。 This article reports the synthesis of optically pure Maythanol, Maytansine. The physical constants and spectral data of the synthesized maytansines and maytansinoids include thin-layer chromatography behavior, melting point, specific rotation, high-speed liquid phase, ultraviolet spectrum, circular dichroism spectrum, infrared spectrum, nuclear magnetic resonance and mass spectrometry With the natural Mayt alcohol, maytansine exactly the same. Biological tests show that the synthesized maytansine has the same antitumor activity as the natural maytansine.