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目的观察埋伏阻生上颌尖牙GCF中IL-8和OCN水平,并探讨其意义。方法选择本院口腔正畸牵引治疗者60例,对GCF中IL-8和OPN水平进行检测,并进行相关性分析。结果正畸治疗第0 h、1 h、24 h、48 h、7 d、14 d、30 d GCF中IL-8浓度分别为(58.47±20.78)ng/ml、(88.63±22.36)ng/ml、(118.63±41.37)ng/ml、(180.33±51.74)ng/ml、(91.46±25.24)ng/ml、(69.45±32.32)ng/ml、(62.32±27.13)ng/ml,治疗后第1 h、24 h、48 h差异有统计学意义(P<0.01);正畸治疗第0 h、1 h、24 h、48 h、7 d、14 d、30 d GCF中OCN浓度分别为(279.35±179.78)ng/ml、(388.63±172.34)ng/ml、(469.26±157.57)ng/ml、(558.64±154.86)ng/ml、(411.49±145.24)ng/ml、(389.47±132.32)ng/ml、(262.32±127.13)ng/ml,治疗后第24 h、48 h、7 d、14 d(P<0.01)差异有统计学意义,30 d后IL-8和OCN基本回复至基线水平(P>0.05);GCF中IL-8水平与OCN呈正相关(r=0.857,P<0.01)。结论 GCF中IL-8和OCN能反映牙周炎症和正畸牙修复情况。
Objective To observe the levels of IL-8 and OCN in impacted maxillary canines GCF, and to explore its significance. Methods 60 cases of Orthodontic Traction in our hospital were selected and the levels of IL-8 and OPN in GCF were detected and their correlations were analyzed. Results The levels of IL-8 in GCF were (58.47 ± 20.78) ng / ml and (88.63 ± 22.36) ng / ml respectively at 0h, 1h, 24h, 48h, 7d, 14d and 30d after orthodontic treatment , (118.63 ± 41.37) ng / ml, (180.33 ± 51.74) ng / ml, (91.46 ± 25.24) ng / ml, (69.45 ± 32.32) ng / ml and (62.32 ± 27.13) ng / The OCN concentrations in GCF at 0 h, 1 h, 24 h, 48 h, 7 d, 14 d and 30 d after orthodontic treatment were (279.35, (388.63 ± 172.34) ng / ml, (469.26 ± 157.57) ng / ml, (558.64 ± 154.86) ng / ml, (411.49 ± 145.24) ng / ml, (389.47 ± 132.32) ng / ml and 262.32 ± 127.13 ng / ml respectively. There was significant difference at 24 h, 48 h, 7 d and 14 d after treatment (P <0.01). After 30 days, IL-8 and OCN returned to baseline level P> 0.05). The level of IL-8 in GCF was positively correlated with OCN (r = 0.857, P <0.01). Conclusion IL-8 and OCN in GCF can reflect periodontal inflammation and orthodontic tooth restoration.