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目的分析急性百草枯中毒的临床特征。方法对45例急性百草枯中毒患者的临床资料进行回顾性分析。结果 45例患者中死亡28例(62.2%),治愈17例(37.8%);恶心、呕吐为最早出现的主要症状;气促为较晚出现的主要体征;死亡原因均为急性呼吸窘迫综合征(ARDS)、呼吸衰竭;血液净化可延缓肝损害的患者发生,但对肝损害的恢复无明显帮助;服毒量越大,死亡率越高,不同服毒量中毒死亡率差异有统计学意义(P<0.01);肺、肝、肾及多器官受损,死亡率明显增加。结论百草枯中毒可致多器官功能损害,预后差,早期综合治疗,可降低病死率。
Objective To analyze the clinical characteristics of acute paraquat poisoning. Methods The clinical data of 45 acute paraquat poisoning patients were retrospectively analyzed. Results Of 45 patients, 28 (62.2%) died and 17 (37.8%) were cured. Nausea and vomiting were the first major symptoms. Shortness of breath was the main symptom to appear later. The causes of death were acute respiratory distress syndrome (ARDS), respiratory failure, blood purification can delay the occurrence of liver damage in patients, but no significant help to the recovery of liver damage; the greater the dose of poisoning, the higher the mortality rate, the difference of poisoning poisoning rates were statistically significant (P <0.01); lung, liver, kidney and multiple organ damage, mortality increased significantly. Conclusion Paraquat poisoning can cause multiple organ damage, poor prognosis, early comprehensive treatment, can reduce the mortality.