论文部分内容阅读
弓状核是位于下丘脑基底部的一个很重要的神经核团，含多种神经元和神经肽类物质，而且有丰富的传入和传出神经纤维，与大脑皮质、边缘系统和下丘脑内部的神经核团有广泛联系，参与多种生理活动的调节，如内分泌、摄食、情绪、痛觉和免疫等，弓状核对红细胞免疫功能的影响如何呢？本实验利用化学损毁的方法，探讨了下丘脑弓状核对红细胞免疫功能的影响。首先，我们通过在大鼠新生期腹腔注射谷氨酸一钠（MSG），建立了下丘脑弓状核损毁的大鼠模型，然后，在成年期，观察了红细胞C3b受体花环率、红细胞免疫复合物花环率。结果显示，在弓状核损毁组这些指标均比注射NaC1对照组和正常组降低，并具有显著的差异（P＜0．01）。提示在弓状核与红细胞免疫功能之间有密切的联系，弓状核能够调节红细胞免疫粘附功能。其机制推测如下，①弓状核可能通过释放神经肽类物质与红细胞膜上相应的受体结合，从而直接调节红细胞的免疫功能。②弓状核可能通过丰富的传入和传出神经纤维，影响大脑皮质，大脑边缘系统及下丘脑的调节功能，从而通过垂体-肾上腺轴，交感神经，间接影响红细胞免疫功能。③弓状核可能通过抑制白细胞免疫系统释放细胞因子，来降低红细胞的免疫功能。
The arcuate nucleus is a very important nucleus located in the basal portion of the hypothalamus and contains a variety of neurons and neuropeptides. It is also rich in afferent and afferent nerve fibers and interacts with the cerebral cortex, the limbic system, and the hypothalamus Internal nerve nuclei have extensive contact, involved in the regulation of a variety of physiological activities, such as endocrine, feeding, emotion, pain and immune, arcuate nucleus on the immune function of red blood cells how? In this experiment, chemical damage method was used to investigate the effect of hypothalamic arcuate nucleus on erythrocyte immune function. First, we established a rat model of hypothalamic arcuate nucleus destruction by intraperitoneal injection of glutamate monosodium glutamate (MSG) in the neonatal rat. Then, in adulthood, we observed the ratio of rosette C3b receptor rosette, erythrocyte immunization Complex wreath rate. The results showed that in the arcuate nucleus destruction group these indicators were lower than those in the NaC1 injection group and the normal group, with significant difference (P <0.01). Tip of the arcuate nucleus and the immune function of erythrocytes are closely linked, arcuate nucleus can regulate erythrocyte immune adhesion function. The mechanism of speculation is as follows, ① arcuate nucleus may release the neuropeptides binding to the corresponding receptors on the red cell membrane, which directly regulate the immune function of red blood cells. The arcuate nucleus may affect the regulation function of the cerebral cortex, the limbic system and the hypothalamus through abundant afferent and afferent nerve fibers, and indirectly affect the immune function of erythrocytes through the pituitary-adrenal axis and sympathetic nerve. ③ arcuate nucleus may inhibit the release of leukocyte immune system cytokines to reduce the immune function of red blood cells.