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目的：研究低剂量Ｘ线全身照射的抑瘤作用，探讨最低有效抑瘤剂量。方法：利用ＮＩＨ系小白鼠在腹股沟区移植腹水型肝癌细胞株后第２天在剂量率为２０ｍＧｙ／ｍｉｎ条件下，给予不同剂量Ｘ线（０，５，１０，３０，５０，７５ｍＧｙ）单次全身照射，荷瘤１个月处死小鼠称瘤体质量，共重复６次实验。结果：５０ｍＧｙ和７５ｍＧｙ组有明显的抑瘤效果（Ｐ＜０．０５），但该两组间无统计学差异，其余各组无明显抑瘤效果。结论：低剂量辐射有明显抑瘤作用，最低有效抑瘤剂量为５０ｍＧｙ，为低剂量辐射临床应用可能性提供可靠的实验依据。
Objective: To study the anti-tumor effect of low-dose X-ray whole-body irradiation and explore the lowest effective antitumor dose. METHODS: NIH mice were treated with different doses of X-rays (0, 5, 10, 30, 50, 75 mGy) on the second day after transplantation of ascites type liver cancer cell lines in the inguinal region on the second day at a dose rate of 20 mGy/min. After whole-body irradiation, the mice were sacrificed 1 month after the tumors were sacrificed and the masses of the tumors were evaluated. The experiment was repeated for 6 times. Results: The 50mGy and 75mGy groups had significant antitumor effect (P<0.05), but there was no statistical difference between the two groups. The rest of the groups had no significant antitumor effect. Conclusion: Low-dose radiation has a significant anti-tumor effect, and the minimum effective anti-tumor dose is 50mGy, which provides a reliable experimental basis for the clinical application of low-dose radiation.