目的 :探讨卵巢切除对大鼠骨组织形态学改变的影响。方法 :将 18只 3月龄雌性大鼠随机分为卵巢切除组及假手术组(对照组 )。术后 3周处死两组大鼠 ,获取股骨远端 1/ 3处骨 ,分别进行石蜡包埋 ,塑料包埋切片及扫描电镜观察。结果 :卵巢切除可引起大鼠骨小梁变细、中断 ,骨小梁表面钙盐沉积减少。结论 :卵巢切除可使大鼠骨吸收增加 ,影响骨的稳定性 ,增加骨折发生的危险性。 Objective: To investigate the effect of ovariectomy on morphological changes of bone in rats. Methods: Eighteen 3-month-old female rats were randomly divided into ovariectomized group and sham-operated group (control group). Three weeks after the operation, two groups of rats were sacrificed and one third of the distal femur were obtained. Paraffin-embedded, plastic-embedded sections and scanning electron microscopy were performed. Results: Ovariectomy could induce the trabecular bone to become thinner and disrupted in rats and reduce the deposition of calcium on the trabecular surface. Conclusion: Ovariectomy can increase the bone resorption in rats, affect the stability of bone and increase the risk of fracture.