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目的了解本地区近年非淋菌性尿道炎(NGU)患者支原体感染及药敏的情况,为有效预防和控制由支原体引起的NGU,正确用药提供参考资料。方法采用支原体培养、鉴定、计数及药敏一体化试剂盒对825例NGU门诊患者进行支原体培养,并对阳性标本进行药敏试验。结果825例中支原体培养阳性712例,阳性率为86.3%;其中解脲支原体(Uu)、人型支原体(Mh)及Uu+Mh混合感染的阳性率分别为70.2%(500/825),3.5%(25/825)和26.3%(187/825)。Uu单纯感染对11种抗生素敏感性最高的是美满霉素和阿奇霉素;耐药性最强的是罗红霉素,其次为司帕沙星。Mh单纯感染对美满霉素、交沙霉素、阿奇霉素敏感性很高(均在90%以上),而对环丙沙星耐药性最强。Uu+Mh混合感染对交沙霉素、阿奇霉素敏感,对环丙沙星和司帕沙星耐药性强。结论近年来本地NGU患者支原体感染率较高,特别是解脲支原体感染,且对罗红霉素、司帕沙星等有较强的耐药性,并有多药耐药现象。目前本地区治疗泌尿生殖道支原体感染的首选抗生素为美满霉素、交沙霉素、阿奇霉素。
Objective To understand the prevalence and susceptibility of mycoplasma in patients with non-gonococcal urethritis (NGU) in recent years in our country and provide references for the effective prevention and control of NGU caused by mycoplasma. Methods Mycoplasma culture was performed in 825 cases of NGU outpatients using mycoplasma culture, identification, counting and drug sensitivity integration kit, and the susceptibility test of positive specimens. Results The positive rate of mycoplasma in 825 cases was 712 (positive rate was 86.3%). The positive rates of Uu, Mh and Uu + Mh were 70.2% (500/825), 3.5 % (25/825) and 26.3% (187/825). Uu infection alone was the most susceptible to 11 antibiotics, minocycline and azithromycin; Roxithromycin was the most resistant, followed by sparfloxacin. Mh infection alone was sensitive to minocycline, josamycin and azithromycin (both above 90%), while ciprofloxacin had the strongest resistance. The mixed infection of Uu + Mh is sensitive to jasminemycin and azithromycin and resistant to ciprofloxacin and sparfloxacin. Conclusion The prevalence of mycoplasma in local NGU patients is high in recent years, especially the infection of Ureaplasma urealyticum, and has strong resistance to roxithromycin, sparfloxacin and so on, and has the multi-drug resistance phenomenon. Currently the treatment of genitourinary tract mycoplasma infection in the region preferred antibiotics for minocycline, josamycin, azithromycin.