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帕金森病(PD)是黑质多巴胺(DA)能神经元变性所致的运动障碍疾病,以静止性震颤、僵直、运动迟缓和姿势反射异常为临床特征。PD 中的免疫反应涉及到免疫细胞和免疫分子,以及复杂的调控网络。该免疫反应有神经损害和神经保护作用,我们就 PD 中的神经保护性免疫进行综述。一、神经保护性免疫的背景近年来发现许多中枢神经系统(CNS)病变都有炎症过程。最初认为 CNS 炎症是有害的,但近
Parkinson’s disease (PD) is a dyskinetic disorder caused by degeneration of dopaminergic neurons in the substantia nigra. It is characterized by resting tremor, stiffness, bradykinesia, and postural reflex abnormalities. The immune response in PD involves immune cells and immune molecules, as well as complex regulatory networks. The immune response has nerve damage and neuroprotection, and we review neuroprotective immunity in PD. First, the background of neuroprotective immunity In recent years, many central nervous system (CNS) lesions have been found to have an inflammatory process. Initially thought of CNS inflammation is harmful, but near