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本文研究了24例动脉粥样硬化性脑梗塞患者和39例正常对照载脂蛋白AI—CⅢ基因簇EcoRI限制性片段长度多态性及不同基因型与总胆固醇、甘油三酯和高密度脂蛋白胆固醇之间的关系。患者与正常对照组R_2等位基因频率分别为0.40和0.12,二组间具极显著性差异(P<0.0001)。R_1R_2基因型个体总胆固醇和甘油三酯高于R_1R_1基因型个体,而高密度脂蛋白胆固醇低于R_1R_1基因型个体。结果显示载脂蛋白AI—CⅢ基因簇遗传变异与动脉粥样硬化性脑梗塞有关,其机制可能是通过调控高密度脂蛋白所致。
In this study, 24 patients with atherosclerotic cerebral infarction and 39 normal control apolipoprotein AI-C Ⅲ gene cluster EcoRI restriction fragment length polymorphism and different genotypes with total cholesterol, triglycerides and high-density lipoprotein The relationship between cholesterol. The frequencies of R 2 alleles in patients and controls were 0.40 and 0.12, respectively, with significant differences between the two groups (P <0.0001). Individuals with R_1R_2 genotype had higher total cholesterol and triglycerides than those with R_1R_1 genotype, while high density lipoprotein cholesterol was lower than those with R_1R_1 genotype. The results showed that the genetic variation of apolipoprotein AI-CⅢ gene cluster was related to atherosclerotic cerebral infarction, which may be caused by the regulation of high density lipoprotein.