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目的研究肾病综合征患者血脂和代谢性激素的特点及脂蛋白a(Lp(a))的相关因素。方法对50例肾病综合征患者的总胆固醇(TC)、三酯甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)、Lp(a)、游离甲状腺激(FT3,FT4)、胰岛素(Ins)的含量进行测定,并与30例正常人比较,分析Lp(a)与其它因素的相关性。结果肾病综合征组TC、LDL-C、TG、ApoB、Lp(a)和Ins水平高于对照组,FT3及FTT4均低于正常对照组,差异均有统计学意义。肾病综合征患者血浆Lp(a)与FT3、FT4呈负相关,与TG呈正相关。结论肾病综合征患者存在血脂水平和代谢激素异常,与Lp(a)含量具有一定相关性。
Objective To investigate the characteristics of blood lipids and metabolic hormones in patients with nephrotic syndrome and the related factors of lipoprotein a (Lp (a)). Methods The total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A (ApoB), Lp (a), free thyroid stimulating hormone (FT3, FT4) and insulin were determined. The levels of Lp (a) and other factors Correlation. Results The levels of TC, LDL-C, TG, ApoB, Lp (a) and Ins in the nephrotic syndrome group were higher than those in the control group, and FT3 and FTT4 were lower than those in the normal control group. Nephrotic syndrome patients plasma Lp (a) and FT3, FT4 was negatively correlated with TG was positively correlated. Conclusions There is a relationship between serum lipids and abnormalities of metabolic hormones in patients with nephrotic syndrome and Lp (a) content.