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目的:为骨质疏松症的预防与治疗提供循证医学证据。方法:循证检索PubMed的Clinical Queries,获取骨质疏松症预防与治疗相关文献,将检索所得文献有选择性的阅读消化提炼,获得可信循证医学证据。结果:不同的检索策略分别获得文献20346篇、2192篇和454篇。文献分析表明,原发性骨质疏松症可使用每月po一次伊班膦酸盐来预防,继发性骨质疏松症可使用每三个月iv一次氯膦酸盐来预防,也可采用静脉滴注唑来膦酸5mg或po5mg利塞膦酸盐。饮茶可作为非药物治疗预防骨质疏松的方法。饮食治疗要多食入一些含钙、磷、维生素及蛋白质丰富的食品,以弥补体内与骨代谢有关的物质的不足。药物治疗可选用补充钙和维生素D钙、降钙素、二膦酸盐。还可采用雌激素补充疗法、物理疗法等。结论:骨质疏松症的防治可采用饮食、运动、物理和药物等综合疗法。
Objective: To provide evidence-based medical evidence for the prevention and treatment of osteoporosis. Methods: Evidence - based PubMed Clinical Queries was searched for relevant literature on prevention and treatment of osteoporosis. The retrieved documents were selectively read for digestion and extraction, and credible evidence - based medical evidence was obtained. Results: 20346 articles, 2192 articles and 454 articles were obtained respectively under different retrieval strategies. Literature analysis shows that primary osteoporosis can be treated once a month with ibandronate to prevent secondary osteoporosis can be used once every three months iv clodronate to prevent, can also be used Intravenous infusion of zoledronic acid 5mg or po5mg risedronate. Drinking tea can be used as a non-drug treatment to prevent osteoporosis. Eat more food and drink some calcium, phosphorus, vitamins and protein-rich foods to make up for the body and the bone metabolism-related substances. Drug treatment can choose to add calcium and vitamin D calcium, calcitonin, bisphosphonates. Can also be used estrogen replacement therapy, physical therapy. Conclusion: The prevention and treatment of osteoporosis can be diet, exercise, physical therapy and drug combination therapy.