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目的国产32磷玻璃微球(32P-GMS)治疗肝癌疗效观察。方法经度股动脉穿刺,导管选择性插管至肝动脉灌注32P-GMS超液化碘油混悬液,治疗原发性肝癌32例;转移性肝癌14例;随机对照组原发性肝癌18例用肝动脉栓塞化疗。结果治疗后3月观察原发性肝癌32P-GMS治疗组病灶缩小>50%6例,50%~25%11例,<25%~10%12例,有效率为90.63%(29/32),对照组18例中14例有效(77.78%),经Ridit分析和X2检验,二组无显著差异。转移性肝癌14例中11例有效。32P-GMS治疗肝癌总有效率86.96%(40/46)。32P-GMS治疗组未出现明显血液毒性。结论32P-GMS肝动脉栓塞是治疗肝癌的有效手段之一。
Objective To observe the curative effect of domestic 32 P-glass microspheres (32P-GMS) in the treatment of liver cancer. Methods Long-term femoral artery puncture was performed. Catheters were selectively inserted into the hepatic artery to perfuse 32P-GMS lipiodol suspension to treat 32 cases of primary liver cancer; 14 cases of metastatic liver cancer; 18 cases of primary liver cancer in randomized control group Hepatic artery embolization chemotherapy. RESULTS: After 3 months of observation, 32% of the 32P-GMS patients in the primary liver cancer group had lesions shrinking >50% in 6 cases, 50% to 25% in 11 cases, <25% to 10% in 12 cases, and the effective rate was 90.63%. 32) Of the 18 cases in the control group, 14 cases were effective (77.78%). There was no significant difference between the two groups by Ridit analysis and X2 test. Of the 14 cases with metastatic liver cancer, 11 were effective. The total effective rate of 32P-GMS in treating liver cancer was 86.96% (40/46). No significant hematologic toxicity was observed in the 32P-GMS group. Conclusion 32P-GMS hepatic artery embolization is one of the effective methods to treat liver cancer.