循证医学显示,高密度脂蛋白(HDL)是心血管疾病的一个独立危险因素。HDL通过逆向转运胆固醇,抵抗低密度脂蛋白(LDL)氧化,保护内皮功能等机制起到了抗动脉粥样硬化(AS),减缓冠状动脉疾病进展的作用。近年来的大量研究显示,HDL可以被氧化,并且被氧化修饰后,不但减弱其抵抗AS的作用 Evidence-based medicine shows that high-density lipoprotein (HDL) is an independent risk factor for cardiovascular disease. HDL plays a role of anti-atherosclerosis (AS) and slowing the progression of coronary artery disease by reversing cholesterol transport, resisting the oxidation of low-density lipoprotein (LDL), and protecting endothelial function. In recent years, a large number of studies have shown that HDL can be oxidized, and oxidative modification, not only weakened its role in resistance to AS