大肠癌是常见的恶性肿瘤,发病率高,预后差。其复发和转移是影响患者疗效和预后的首要因素。为了提高其早期诊断率及治疗效果,多年来外科及病理学者们一直致力于寻找1种代表恶性肿瘤生物学行为的敏感指标及合理的肿瘤分期方法。肿瘤芽殖是浸润转移过程的第一步,即癌细胞与原发癌 Colorectal cancer is a common malignancy with high incidence and poor prognosis. Its recurrence and metastasis is the primary factor affecting the efficacy and prognosis of patients. In order to improve its early diagnosis and treatment, surgical and pathological scholars have been looking for a sensitive indicator of the biological behavior of malignant tumors and a reasonable tumor staging method for many years. Tumor budding is the first step in the process of invasion and metastasis, namely cancer cells and primary cancer