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鲁米诺增强的化学光反应(CL)也许可用于测定人单核细胞对抗D致敏红细胞的代谢反应。用此方法测定的母亲抗D功能活性与D(+)胎儿出生后的新生儿溶血病(HDN)的严重程度有相关性。然而,从有妇女抗D的功能活性水平预测的中度到重度HDN的母亲偶尔也可分娩未预料到的发病轻微的D(+)婴儿。目前的研究表明15名这样的妇女中有12名其血清中含有结合单核细胞的IgG抗体,该抗体可阻断Fcr-RI和抑制单核细胞对单克隆抗D致敏红细胞的CL反应;相反,在11例与抗D活性相符但分娩出严重HDN婴儿的妇女中,只有4
Luminol enhanced chemiluminescence (CL) may be useful for determining the metabolic response of human monocytes against D-sensitized erythrocytes. The maternal anti-D-functional activity measured by this method correlated with the severity of neonatal hemolytic disease (HDN) after D (+) fetus birth. However, mothers with moderate to severe HDN predicted from women with functional anti-D activity can occasionally deliver unanticipated morbidity to mild D (+) infants. Current studies show that 12 out of 15 women in their sera contain IgG-bound monocyte-derived antibodies that block the FcR-RI and inhibit the CL response of monocytes to monoclonal anti-D-sensitized erythrocytes; In contrast, out of 11 women with anti-D activity who gave birth to severe HDN infants, only 4