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我们采用吗啡和纳洛酮研究了吗啡对大鼠皮质酮分泌的影响,结果表明:(1)单独注射吗啡或乙酰胆碱,均使皮质酮分泌增多,而二者合用,则相互抵消;(2)单独注射去甲肾上腺素,可抑制皮质酮分泌;吗啡可抵消此作用;(3)吗啡的作用可被纳洛酮所翻转。本实验提示,内源性鸦片样物质参预CRH分泌的调节。
Morphine and naloxone were used to study the effects of morphine on corticosterone secretion in rats. The results showed that: (1) morphine and acetylcholine injection alone increased the secretion of corticosterone, Noradrenaline alone can inhibit corticosterone secretion; morphine can counteract this effect; (3) morphine can be reversed by naloxone. This experiment suggests that endogenous opioid substances participate in the regulation of CRH secretion.