本文报道二例急性脊髓炎伴乙型戊型肝炎病毒重叠感染。例1女,56岁,因肢体无力、大小便困难两周入院。患者入院三周前感冒、乏力,腹胀,起病四天后感肩背酸痛、四肢麻木、肌力减退、行走困难,继以排尿排便障碍。体检:无黄疸,心肺无异常,腹饱满、软,肝肋下3cm,C_5以下痛觉减退,触觉存在,上肢肌力Ⅰ～Ⅱ,下肢肌力Ⅲ,踝阵挛(+),巴氏征(+),腱反射减弱, This article reports two cases of acute myelitis with hepatitis E virus overlapping infection. Example 1 Female, 56 years old, due to limb weakness, difficulty in urinating two weeks admitted. Patients admitted to hospital three weeks ago, colds, fatigue, bloating, flu after 4 days onset of shoulder pain, limb numbness, muscle weakness, walking difficulties, followed by urination defecation disorders. Physical examination: no jaundice, no abnormal heart and lung, full belly, soft, liver ribs 3cm, C_5 following pain decreased, the presence of tactile, upper limb muscle strength Ⅰ ~ Ⅱ, lower limb muscle strength Ⅲ, ankle clonus (+ +), Weakened tendon reflex,