论文部分内容阅读
哺乳动物细胞的任何特征包括恶性细胞和正常细胞的不同特征都在细胞表面得到表达,肿瘤细胞表面特征的改变是肿瘤细胞异常生长和恶性行为的基础。糖蛋白及糖脂构成细胞膜的主要成份,所以,细胞表面的糖偶合物在恶变中具有重要性,这些糖偶合物通过增加流动、分泌和(或)从肿瘤细胞表面释放进入血循环中. 已测出各种恶性肿瘤患者的血清或血浆中的糖偶合物如总唾液酸、脂结合唾液酸、粘蛋白和蛋白结合己糖的水平提高,表明它们在诊断或监控治疗上是有作用
Any features of mammalian cells, including malignant cells and normal cells, are expressed on the cell surface. Changes in the surface characteristics of tumor cells are the basis for abnormal growth and malignant behavior of tumor cells. Glycoproteins and glycolipids constitute the main components of the cell membrane, so the sugar conjugates on the cell surface are important in malignant transformation. These sugar conjugates increase their flow, secretion, and/or release from the tumor cell surface into the blood circulation. Increased levels of sugar conjugates such as total sialic acid, lipo-associated sialic acid, mucin, and protein-bound hexoses in serum or plasma of patients with various malignancies indicate that they are useful in diagnosing or monitoring treatment.