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目的 观察TP方案 (泰素 +顺铂 )和NP方案 (诺维本 +顺铂 )治疗IIIb～IV期非小细胞肺癌近期疗效及毒副反应。方法 使用TP方案治疗晚期非小细胞肺癌 2 2例 ,其中初治 12例 ,复治 10例 ,IIIb期 12例 ,IV期 10例 ,给予泰素 (Toxal) 13 5mg/m2 ,ivgtt,d1,顺铂 (PDD) 2 5mg/m2 ,ivgtt,d1～ 3 。使用NP方案治疗晚期非小细胞肺癌 2 8例 ,其中初治 16例 ,复治 12例 ,IIIb期 16例 ,IV期 12例 ,给予诺维本 (NVB) 2 5mg/m2 ,ivgtt ,d1,8。顺铂用法同TP方案。结果 有效率 :TP方案为 45 .45 % ,其中初治 5 0 % ,复治 40 % ;NP方案为42 .85 % ,其中初治 5 0 % ,复治 3 3 .3 %。两者无明显差别 (P >0 .0 5 )。毒副作用NP组骨髓抑制较重 ,白细胞减少率占 89.3 % ,III度+IV度 42 .86% ;TP组白细胞减少率占 5 9.1% ,III度 +IV度占 18.18% ;NP组脱发、静脉炎、恶心呕吐等反应均较TP组重。结论 TP方案和NP方案治疗IIIb～IV期非小细胞肺癌效果均较好 ,但诺维本组治疗毒副作用较大 ,对于两药的选择要结合患者的实际情况全面考虑。
Objective To observe the short-term curative effect and toxicity of TP regimen (taxol + cisplatin) and NP regimen (nobustamycin + cisplatin) for stage IIIb-IV non-small cell lung cancer. Methods Twenty two cases of advanced non-small cell lung cancer were treated with TP regimen. Among them, 12 cases were untreated, 10 cases were retreated, 12 cases were treated in stage IIIb and 10 cases were treated in stage IV. Toxal 135 mg / m2, ivgtt, d1, Cisplatin (PDD) 25mg / m2, ivgtt, d1 ~ 3. There were 28 cases of advanced non-small cell lung cancer treated with NP regimen, including 16 cases of initial treatment, 12 cases of rehospitalization, 16 cases of stage IIIb and 12 cases of stage IV. NVB 2.5 mg / m2, ivgtt, d1, 8. Cisplatin use the same TP program. Results The effective rate was 45.45% for the TP regimen, including 50% of initial treatment and 40% of retreatment; NP of 42.85%. The initial treatment was 50% and retreatment was 33.3%. There was no significant difference between the two (P> 0.05). Toxicity and side effects NP group had severe myelosuppression, leukopenia accounted for 89.3%, III degree + IV degree 42.86%; TP group leukopenia accounted for 5 9.1%, III degree + IV degree accounted for 18.18%; NP group hair loss, Inflammation, nausea and vomiting and other reactions were heavier than the TP group. Conclusion Both TP and NP regimens are effective in the treatment of stage IIIb-IV non-small cell lung cancer, but the toxicity and side effects of novetopromycin in treatment are high. The selection of both drugs should be fully considered in combination with the actual situation of patients.