目的:研究盐酸右美托咪定应用于小儿头面部外伤手术麻醉的临床效果和安全性的观察。方法:将90例进行头面部外伤手术的患儿随机分为盐酸右美托咪定组(应用盐酸右美托咪定进行麻醉)、七氟醚组(应用七氟醚麻醉)和对照组(利多卡因表面麻醉),每组32例。观察比较3组术中麻醉效果和不良反应情况。结果:盐酸右美托咪定组镇静效果与七氟醚组相当,但不良反应发生率低于七氟醚,且镇痛效果优于七氟醚。差异有统计学意义(P<0.05);而盐酸右美托咪定组镇痛效果也明显高于对照组,差异显著(P<0.05)。结论:盐酸右美托咪定应用于小儿头面部外伤手术的麻醉,镇静镇痛效果优越,安全性高,不良反应发生率低,且操作简单,值得临床推广应用。 Objective: To study the clinical efficacy and safety of dexmedetomidine hydrochloride for anesthesia in pediatric head and face trauma. Methods: 90 children with head and face trauma were randomly divided into dexmedetomidine hydrochloride group (dexmedetomidine hydrochloride for anesthesia), sevoflurane group (sevoflurane anesthesia) and control group ( Lidocaine topical anesthesia), 32 in each group. The effects of anesthesia and adverse reactions in the three groups were observed and compared. Results: The sedation effect of dexmedetomidine hydrochloride group was similar to that of sevoflurane group, but the incidence of adverse reactions was lower than that of sevoflurane, and the analgesic effect was better than sevoflurane. The difference was statistically significant (P <0.05); while the dexmedetomidine hydrochloride group analgesic effect was significantly higher than the control group, the difference was significant (P <0.05). Conclusion: Dexmedetomidine hydrochloride for anesthesia in children with head and face trauma surgery has the advantages of superior analgesic effect, high safety, low incidence of adverse reactions, and simple operation, which is worthy of clinical application.