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腹腔注射阿霉素可以使大鼠产生实验性心肌病。大剂量注锰可以加重阿霉素的心脏毒性作用,加重心力衰竭和心肌细胞与间质水肿。红细胞内锰的蓄积可以导致硒和含硒酶的含量与活性发生改变。錳亦可以明显抑制大鼠生长。
Intraperitoneal injection of doxorubicin can produce experimental cardiomyopathy in rats. High-dose manganese injection can aggravate cardiotoxicity of doxorubicin, aggravating heart failure and myocardial cell and interstitial edema. The accumulation of manganese in erythrocytes can lead to changes in the content and activity of selenium and selenoenzymes. Manganese also significantly inhibited rat growth.