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简介 克山病是我省主要地方病之一。本病早期常不易辨认。一旦症状明显,心肌往往已蒙受较严重损害,因此,早发现、早诊断是克山病防治工作的重要环节。去年克山病研究室生化组和免疫组分别对克山病血清乳酸脱氢酶同功酶谱和抗心肌抗体的变化作了研究,初步确定了两者在克山病诊断上的意义。乳酸脱氢酶与心肌抗原是心肌内天然存在的物质,当心肌受损伤(如克山病)时,这两种物质就被释放入血。前者入血后使血清内该种酶的酶谱发生改变;后者入血后,就可能导致抗体的形成。所以,通过检测血清内乳酸脱氢酶同功酶谱和抗心肌抗体,可了解心肌损伤的情况。这两项指标经该室同志在克山病区与非病区,病人与健康人身上反复验证,已初步证明了它们的实用价值。其中乳酸脱氢酶谱检查用血量甚微,能够比较灵敏地检查出新鲜的心肌损伤,对病区内已经发作或即将发作的亚急性克山病人的早期诊断有意义。抗心肌抗体在慢型、亚急型和潜型克山病人都有变化,而对于检出曾经发生过心肌损伤,目前症状隐匿的病人(如潜型克山病人)似有较大意义。 有关这两项工作的具体细节和详细结果已有两篇专文在我校1974年《克山病科研资料》发表,本文将其主要内容作简明综述。
Brief introduction Keshan disease is one of the major endemic diseases in our province. The disease is often not easy to identify early. Once the symptoms are obvious, the myocardium often has suffered more serious damage, therefore, early detection and early diagnosis is an important part of prevention and treatment of Keshan disease. Last year Keshan Disease Research Biochemical group and immune group were Keshan disease serum lactate dehydrogenase isoenzyme Zymogram and anti-myocardial antibodies were studied to determine the two Keshan disease in the diagnosis of the significance. Lactate dehydrogenase and cardiac antigens are naturally occurring substances in the myocardium, which are released into the blood when the heart muscle is damaged (eg Keshan disease). The former changes the enzyme zymogram in the serum after entering the blood; the latter may lead to the formation of antibodies after it enters the bloodstream. Therefore, by detecting serum lactate dehydrogenase isoenzyme and anti-myocardial antibodies, can understand the situation of myocardial injury. The two indicators by the room comrades in Keshan ward and non-ward, patients and healthy people repeatedly verified that they have initially proved their practical value. Lactic acid dehydrogenase spectroscopy in which blood is used for very small, can be more sensitive to detect fresh myocardial injury, the disease has been attacked or about the onset of subacute Keshan patients with early diagnosis of significance. Anti-myocardial antibodies in slow, subacute and latent Keshan patients have changed, and for the detection of myocardial damage has occurred, the current symptoms of hidden patients (such as latent Keshan patients) may have greater significance. Two specific articles have been published on the “Keshan Disease Scientific Research Materials” published by our school in 1974. The main contents of this article are briefly summarized.